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KMID : 0376219750120010253
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Chonnam Medical Journal
1975 Volume.12 No. 1 p.253 ~ p.265
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Effects of Intraventricular Drugs on Blood Pressure of Rabbits with Augmented Intracranial Pressure
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Abstract
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1. Effects of intraventricular (i. VT.) norepinephrine, 5-hydoxytryptamine and dopamine on blood pressure of urethane-anesthetized rabbits with augmented intracranial pressure (40-60 mmHg) were investigated, influences of various blocking agents on the effects were also studied.
2. Intraventricular norepinephrine (100 ㎍), 5-hydroxytryptamine (200 ㎍) and, dopamine (400 ㎍) did not produce pressor responses in rabbits with normal´ intracranial pressure, while they produced pressor responses in rabbits with augmented intracranial pressure.
3. The pressor responses to i. VT. norepinephrine were markedly inhibited after i. VT. phenoxybenzamine and slightly inhibited after i. VT. yohimbine and ergotamine. Intraventricular regitine, deseril, morphine and haloperidol did not affect the responses to i. VT. norepinephrine.
4. The pressor responses to i. VT. 5-hydroxytrptamine were markedly inhibited after i. VT. deseril, morphine and phenoxybenzamine, but not affected-after´ i. VT. regitine and haloperidol.
5. The pressor responses to i. VT. dopamine were markedly inhibited after i. VT. haloperidol, but´ not affected. after i. VT. phenoxybenzamine and deseril.
6. The above results suggest that free norepinephrine, 5-hydroxytryptamine and dopamine in brain may produce hypertension when the intracranial pressure is augmented.
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